Optimal ROS Signaling Is Critical for Nuclear Reprogramming
نویسندگان
چکیده
منابع مشابه
I-12: Nuclear Reprogramming in Bovin Somatic Cell Nuclear Transfer
Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
متن کاملActivation of Innate Immunity Is Required for Efficient Nuclear Reprogramming
Retroviral overexpression of reprogramming factors (Oct4, Sox2, Klf4, c-Myc) generates induced pluripotent stem cells (iPSCs). However, the integration of foreign DNA could induce genomic dysregulation. Cell-permeant proteins (CPPs) could overcome this limitation. To date, this approach has proved exceedingly inefficient. We discovered a striking difference in the pattern of gene expression ind...
متن کاملStoichiometry of transcription factors is critical for cardiac reprogramming.
D irect reprogramming of fibroblasts into cardiomyocytes holds great potential for cardiovascular disease research and treatment. This new technology may be used for patient-specific drug screening, cardiac disease modeling, and regen-erative purposes. We reported first that a combination of 3 cardiac-specific transcription factors, Gata4 (G), Mef2c (M), and Tbx5 (T), constituted the minimum re...
متن کاملNuclear reprogramming.
There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promising applications, most notably in healthcare through the development of human disease models and pa...
متن کاملCritical factors for cardiac reprogramming.
Cellular reprogramming achieved by somatic nuclear transfer or cell fusion has long been recognized.1 The potency of specific transcription factors as cell fate determinants was first demonstrated by the discovery of MyoD, a master regulator for skeletal muscle differentiation, and by the subsequent identification of several genes as lineageconverting transcription factors in blood cells.2,3 Th...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2016
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2016.03.084